CANNABIS & CHRONIC ILLNESS

Joint instability, chronic pain, and inflammation are major struggles for people with EDS. CBD has anti-inflammatory properties that may reduce tissue swelling and muscle pain.

THC can alter pain perception, reducing discomfort. Many with EDS find that combining CBD & THC offers a synergistic effect, helping to manage both inflammation and neuropathic pain.

Potential Benefits for EDS:

Pain relief

Reduced inflammation

Improved muscle relaxation

MCAS involves mast cells releasing too many histamines, causing widespread inflammation, allergic-like reactions, and gut issues. CBD has been studied for its mast cell-stabilizing effects, potentially reducing degranulation (the release of histamine and inflammatory mediators).

High-CBD strains may help reduce flare-ups, but it’s important to start with small doses due to unpredictable reactions.  

Potential Benefits for MCAS: 

Mast cell stabilization

Anti-inflammatory effects

Possible reduction in histamine-related reactions

Caution: Some MCAS patients react negatively to cannabis, so it’s best to start low and go slow.

POTS (Postural Orthostatic Tachycardia Syndrome) affects heart rate, blood pressure, and autonomic nervous system function. CBD interacts with serotonin receptors, which can help regulate stress response and heart rate.

Some high-THC strains can raise heart rate, so many POTS patients prefer high-CBD, low-THC strains for symptom relief. 

Potential Benefits for POTS: 

Nervous system regulation 

Lowered stress response

May help with dizziness & heart rate fluctuations  

Caution: THC can increase heart rate, so low-THC strains are generally a better choice for POTS.

Cannabis terpenes add therapeutic effects beyond cannabinoids. Some helpful terpenes include:

•Myrcene: Sedative, muscle relaxant (found in mangoes, hops).

•Linalool: Calming, anti-anxiety (also found in lavender).

•Beta-Caryophyllene: Anti-inflammatory, interacts with CB2 receptors.

Best Strains for Symptom Relief:

•ACDC – High CBD, minimal THC, calming without sedation.

•Harlequin – Balanced CBD-to-THC, mild relaxation.

•Charlotte’s Web – High-CBD, low-THC, anti-inflammatory properties.

•Cannabis isn’t one-size-fits-all. Response varies based on genetics, sensitivities, and conditions. 

•CBD-dominant strains are often best for EDS, MCAS, and POTS due to their anti-inflammatory and calming effects.

•Always start with low doses and choose lab-tested products to avoid contaminants.

•Work with a healthcare provider to find the best approach for your unique needs.

Cannabis research is still evolving, but many with EDS, MCAS, and POTS have found relief using carefully selected strains. If you’re considering trying cannabis, tracking your reactions and working with a doctor can help tailor a safe and effective approach.